CICA · Interdisciplinary Centre for Chemistry and Biology · Universidade da Coruña nanotoxgen@udc.es

Publications

Scientific publications

Peer-reviewed articles published by members of NanoToxGen since the group was created in 2021.

2026
  1. Lema-Arranz, C., Hemadeh, A., Fernández-Bertólez, N., Cibeira, N., López-López, R., Costa, S., Millán-Calenti, J.C., Lorenzo-López, L., Valdiglesias, V., Laffon, B. (2026). Association of inflammatory biomarkers with physical and cognitive frailty in a Spanish population of older adults. Geroscience. 10.1007/s11357-025-01931-z
2025
  1. Touzani, A., Ramos-Pan, L., Fernández-Bertólez, N., Fraga, S., Laffon, B., Valdiglesias, V. (2025). Systematic review on toxicological effects of platinum nanoparticles: towards their use as safe biomedical tools. Mut Res Rev 796:108554. DOI
  2. Maurya MR, Nandi M, Kumar S, Gupta P, Avecilla F. (2025). Symmetrical Bis-Hydrazone Ligand-Based Binuclear Oxido/Dioxido-Vanadium(IV/V) Complexes: Synthesis, Reactivity, and Catalytic Applications for the Synthesis of 2-Phenylquinazolin-4-(3H)-ones. Inorg Chem 64(4):1734-1751. DOI
  3. Mathot E, Hemadeh A, Knoop V, Bautmans I, Lema-Arranz C, Lorenzo-López L, Valdiglesias V, Laffon B. (2025). The effect of physical interventions in older adults on inflammatory markers (IL-6, IL-10, CRP, TNF-α): an umbrella review of systematic reviews and meta-analyses. Innov Aging 9(7):igaf072. DOI
  4. Hemadeh, A., Lema-Arranz, C., Bonassi, S., Buscarini, L., Infarinato, F., Romano, P., Alessia, F., Marinozzi, F., Bini, F., Fernández-Bertólez, N., Pásaro, E., Lorenzo-López, L., Valdiglesias, V., Laffon, B. (2025). Lifestyle, environment and other major determinants of frailty in older adult. A population-based study from the UK Biobank. Biogerontology 26, 100. DOI
  5. Esteves, F., Madureira, J., Costa, C., Pires, J., Barros, B., Alves, S., Vaz, J., Oliveira, M., Slezakova, K., Fernandes, A., Pereira, M.C., Morais, S., Valdiglesias, V., Bonassi, A., Costa, S. (2025). Occupational Exposure to Wildland Firefighting and Its Effects on Systemic DNA Damage. Int. J. Hyg. Environ. Health 266:114576. DOI
  6. Fernández-Bertólez, N., Touzani, A., Ramos-Pan, L., Reis, A.T., Teixeira, J.P., Laffon, B., Valdiglesias, V. (2025). Biocompatibility testing and antioxidant properties of cerium dioxide nanoparticles in human nervous system cells. Archives of Toxicology 6. DOI
  7. Da Lama, A., Fernández-Bertólez, N., Colás, N., Nó, M., Ramos-Cabrer, P., Valdiglesias, V., Sarandeses, L.A., Martínez, M. (2025). Synthesis of BODIPYs using organoindium reagents and survey of their viability and cell uptake on nervous system cells. Bioorganic Chemistry 155:108107. DOI
  8. Fernández-Bertólez, N., Martínez, L., Ramos-Pan, L., Touzani, A., Carla, S., Laffon, B., Valdiglesias, V. (2025). In vitro and in vivo assessment of nanoceria biocompatibility for their safe use in nervous system applications. Journal of Hazardous Materials 486:137041. DOI
2024
  1. Maurya, M.R., Nandi, M., Kumar, N., Avecilla, F. (2024). Nitrogen-Bridged Symmetrical Homogeneous and Heterogeneous Binuclear Dioxidomolybdenum(VI) Complexes and Their Catalytic Potential for Efficient Synthesis of 2-Amino-3-Cyano-4H-Chromenes/Pyrans. Chemistry 15:e202400631. DOI
  2. Maurya, M.R., Kumar, N., Avecilla, F. (2024). Controlled Modification of Triaminoguanidine-Based μ3 Ligands in Multinuclear [VIVO]/[VVO2] Complexes and Their Catalytic Potential in the Synthesis of 2-Amino-3-cyano-4H-pyrans/4H-chromenes. Inorg Chem 63(5):2505-2524. DOI
  3. Maurya, M.R., Nandi, M., Chaudhary, P.K., Singh, S., Avecilla, F., Prasad, R., Ghosh, K. (2024). Catalytic, Antifungal, and Antiproliferative Activity Studies of a New Family of Mononuclear [VIVO]/[VVO2] Complexes. Inorg Chem 63(1):714-729. DOI
  4. Fernández-Bertólez, N., Alba-González, A., Touzani, A., Ramos-Pan, L., Méndez, J., Reis, A.T., Quelle-Regaldie, A., Sánchez, L., Folgueira, M., Laffon, B., Valdiglesias, V. (2024). Neurotoxicity of zinc oxide nanoparticles: cellular and behavioural effects. Chemosphere 363:142993.
  5. González-Rosales, E., Martínez, L., Valdiglesias, V., Insua A. (2024). A New Molecular Method for Fast Differentiation of Cockles Cerastoderma edule and Cerastoderma glaucum. Conservation Genetics Resources. DOI
  6. Mohyuddin, H., Laffon, B., Teixeira, J.P., Costa, S. et al. (2024). Toxoplasma gondii IgG Serointensity Is Positively Associated With Frailty. The Journals of Gerontology, Series A. DOI
  7. Lorenzo-López, L., Cibeira, N., Hemadeh, A. et al. (2024). Association between dimensions of cognitive reserve proxies and frailty phenotype: data from UK Biobank. GeroScience. DOI
2023
  1. Pilon, A., Avecilla, F., Rácz, B., Gátszegi, G.T., Spengler, G., Robalo, M.P., Enyedy, É.A., Garcia, M.H., Valente, A. (2023). Iron(II)-cyclopentadienyl compounds are cytotoxic against colon adenocarcinoma cell lines: Ethylenebis(diphenylphosphane) vs. triphenylphosphane. J Inorg Biochem 249:112386. DOI
  2. Ramos-Pan, L., Touzani, A., Fernández-Bertólez, N., Fraga, S., Laffon, B., Valdiglesias, V. (2023). Exposure to gold nanoparticles: Impact on genetic material. Mutation Research – Genetic Toxicology and Environmental Mutagenesis 900, 503827.
2022
  1. Giacconi, R., Laffon, B., Costa, S., Teixeira-Gomes, A. et al. (2022). Association of Torquetenovirus viremia with physical and cognitive frailty in three independent European cohorts. Gerontology. DOI
  2. Collins, A., Moller, P., Gajski, G., Vodenkova, S., Valdiglesias, V. et al. (2022). Measuring DNA damage with the comet assay: a compendium of protocols. Nature Protocols 18(3):929-989.
  3. Lorenzo-López, L., Lema-Arranz, C., Fernández-Bertólez, N., Costa, S., Costa, C., Teixeira, J.P., Pásaro, E., Valdiglesias, V., Laffon, B. (2022). Relationship between DNA damage measured by the comet-assay and cognitive function. Mutat Res Genet Toxicol Environ Mutagen 883-884:503557. DOI
  4. Maestro, M., Seoane, S. (2022). The Centennial Collection of VDR Ligands: Metabolites, Analogs, Hybrids and Non-Secosteroidal Ligands. Nutrients 14, 4927. DOI
  5. Fernández-Bertólez, N., Lema-Arranz, C., Fraga, S., Teixeira, J.P., Pásaro, E., Lorenzo-López, L., Laffon, B., Valdiglesias, V. (2022). Suitability of salivary leucocytes to assess DNA repair ability in human biomonitoring studies by the challenge-comet assay. Chemosphere 307:136139. DOI
  6. Mato-López, L., Sar-Rañó, A., Riopedre Fernández, M. et al. (2022). Relationship between structure and cytotoxicity of vanadium and molybdenum complexes with pyridoxal derived ligands. Journal of Inorganic Biochemistry 235:111937. DOI
  7. Maurya, M.R., Maurya, S.K., Kumar, N., Avecilla, F., Gupta, P. (2022). Substituent Controlled Synthesis of Dioxidomolybdenum(VI) Complexes. European Journal of Inorganic Chemistry 23: 1-22. DOI
  8. Valdiglesias, V. (2022). Cytotoxicity and Genotoxicity of Nanomaterials. Nanomaterials 12(4):634. DOI
  9. Opattova, A., Langie, S., Milic, M., Collins, A. et al. (2022). A pooled analysis of molecular epidemiological studies on modulation of DNA repair by host factors. Mutat Res Genet Toxicol Environ Mutagen 876-877, 503447. DOI
  10. Maurya, M.R., Chauhan, A., Verma, A., Kumar, U., Avecilla, F. (2022). Amine-functionalized titanium dioxide supported dioxidomolybdenum(VI) complexes as functional model for phenoxazinone synthase enzyme. Catalysis Today 388-389: 274-287. DOI
  11. Teixeira-Gomes, A., Laffon, B., Valdiglesias, V. et al. (2021). Exploring Early Detection of Frailty Syndrome in Older Adults. Antioxidants 10(12):1975. DOI
  12. Maurya, M.R., AC, Avecilla, F. (2022). Synthesis, characterization and biomimetic activity of heterogenized dioxidomolybdenum(VI) and analogous homogeneous complexes. ChemistrySelect 7(30): 1-19. DOI
  13. Costa, C., Assunção, R., Sequeira, D., Esteves, F., Valdiglesias, V., Laffon, B., Teixeira, J.P., Madureira, J. (2022). From trihalomethanes chronic daily intake through multiple exposure routes to cancer and non-cancer health risk assessment. Sci Total Environ 151790. DOI
  14. Seoane, S., Gogoi, P., Zárate-Ruíz, A. et al. (2022). Design, Synthesis, Biological Activity, and Structural Analysis of Novel Des-C-Ring and Aromatic-D-Ring Analogues of 1α,25-Dihydroxyvitamin D3. J Med Chem 65(19):13112-13124. DOI
2021
  1. Bonassi, S., Ceppi, M., Moller, P., Azqueta, A. et al. (2021). DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death. Scientific Reports 11(1):16793. DOI
  2. Valdiglesias, V., Fernández-Bertólez, N., Lema-Arranz, C., Rodríguez-Fernández, R., Pásaro, E., Reis, T., Teixeira, J.P., Costa, C., Laffon, B. (2021). Salivary leucocytes as in vitro model to evaluate nanoparticle-induced DNA damage. Nanomaterials 11(8):1930. DOI
  3. Fernández-Bertólez, N., Brandao, F., Pásaro, E., Teixeira, J.P., Costa, C., Laffon, B., Valdiglesias, V. (2021). Suitability of the in vitro cytokinesis-block micronucleus test for genotoxicity assessment of TiO2 nanoparticles on SH-SY5Y cells. Int J Mol Sci 22(16):8558. DOI
  4. Fernández-Bertólez, N., Azqueta, A., Pásaro, M., Laffon, B., Valdiglesias, V. (2021). Salivary leucocytes as suitable biomatrix for the comet assay in human biomonitoring studies. Arch Toxicol 31, 1-9. DOI
  5. Laffon, B., Sánchez-Flores, M., Fernández-Bertólez, N., Pásaro, E., Valdiglesias, V. (2021). Applicability of flow cytometry γH2AX assay in population studies. Arch Toxicol 95(5):1843-1851. DOI
  6. Møller, P., Bankoglu, E.E., Stopper, H. et al. (2021). Collection and storage of human white blood cells for analysis of DNA damage and repair activity using the comet assay in molecular epidemiology studies. Mutagenesis geab012. DOI
  7. Milić, M., Ceppi, M., Bruzzone, M. et al. (2021). The hCOMET project: international database comparison for results with the comet assay in human biomonitoring. Mutation Research – Reviews in Mutation Research 787, 108371. DOI
  8. Laffon, B., Bonassi, S., Costa, S., Valdiglesias, V. (2021). Genomic instability as a main driving factor of unsuccessful ageing. Mutation Research – Reviews in Mutation Research 787:108359. DOI
  9. Valdiglesias, V., Sánchez-Flores, M., Fernández-Bertólez, J., Au, W., Pásaro, E., Laffon, B. (2021). Expanded usage of the Challenge-Comet assay as a DNA repair biomarker in human populations. Archives of Toxicology 94:4219–4228. DOI