Happy to share our last work describing the effects of zinc oxide (ZnO) nanoparticles on glial cells and zebrafish, and the influence of released Zn ions on the obtained results. The study was performed in the frame of NanoAssess project (enlace a Proyecto), funded by Spanish Ministry of Science and Innovation.
ZnO nanoparticles are among the most widely used nanomaterials. However, despite their extensive use and being among the most studied NP from a toxicological point of view, much remains unknown about their toxicological profile. Results from our study confirmed that ZnO nanoparticles induce morphological alterations and decrease the viability of human glial cells, the majority cell type in central nervous system. Besides, although there were no signs of acute toxicity in zebrafish embryos, a decrease in hatching was found after exposure to ZnO nanoparticles. The Zn2+ ions released by nanoparticles was not found to be entirely responsible for the effects observed in glial cells, but they were likely to be responsible for the decrease in zebrafish hatching rate.
The link to the article: Effects of Zinc Oxide Nanoparticle Exposure on Human Glial Cells and Zebrafish Embryos https://www.mdpi.com/1422-0067/24/15/12297